Many users have reported the issue of winsxs folder getting increased in size. As these files under %windir%\winsxs\ManifestCache\ are used by the Windows Update mechanism in Windows Server 2008 and Windows Vista. It acts like a cache and is capped at a certain size, it's safe to delete these files.
You may refer to the following steps to remove the file under the %windir%\winsxs\ManifestCache\ to release some disk space that the WinSXS folder takes.
Run the following commands from an elevated command prompt:
Net stop trustedinstaller
NOTE: Wait for it to stop and ensure it stops successfully. If you are unable to stop the service, you may need to restart your machine.
Takeown /f %windir%\winsxs\ManifestCache\*
Icacls %windir%\winsxs\ManifestCache\* /GRANT administrators:F
Del /q %windir%\winsxs\ManifestCache\*
